Turning a Scorpion Toxin into an Antitumor Miniprotein
نویسندگان
چکیده
منابع مشابه
Turning a scorpion toxin into an antitumor miniprotein.
The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53 and are important molecular targets for anticancer therapy. Grafting four residues of p53 critical for MDM2/MDMX binding to the N-terminal alpha-helix of BmBKTx1, a scorpion toxin isolated from the venom of the Asian scorpion Buthus martensi Karsch, converts the miniature protein in...
متن کاملTransduction of the scorpion toxin maurocalcine into cells. Evidence that the toxin crosses the plasma membrane.
Maurocalcine (MCa) is a 33-amino-acid residue peptide toxin isolated from the scorpion Scorpio maurus palmatus. External application of MCa to cultured myotubes is known to produce Ca2+ release from intracellular stores. MCa binds directly to the skeletal muscle isoform of the ryanodine receptor, an intracellular channel target of the endoplasmic reticulum, and induces long lasting channel open...
متن کاملTurning an idea into a grant.
Once one has an idea for a potential research project, the next step is to develop a research hypothesis. This should not be done in a vacuum but is best done as a ‘‘brainstorming’’ exercise with colleagues with a similar research or clinical interest. A research mentor is vital to this process for the novice investigator. This process serves several purposes. First, it will allow one to clearl...
متن کاملTurning an info-glut into a library.
Kathryn Calame C. Thomas Caskey Dennis W. Choi John M. Coffin Paul J. Crutzen James E. Dahlberg Robert Desimone Bruce F. Eldridge Paul T. Englund Richard G. Fairbanks Douglas T. Fearon Harry A. Fozzard Klaus Friedrich Theodore H. Geballe John C. Gerhart Roger 1. M. Glass Stephen P. Goff Peter N. Goodfellow Corey S. Goodman Ira Herskowitz Eric F. Johnson Stephen M. Kosslyn Michael LaBarbera Nico...
متن کاملThe scorpion toxin and the potassium channel
The structure of a complex containing a toxin bound to a potassium ion channel has been solved for the first time, revealing how scorpions have designed toxins that can recognize and target the filter that controls the movement of potassium ions through these channels.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2008
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja8042036